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Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld
Phys. Rev. Lett. 80, 627 – Published 19 January 1998
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Abstract

We report observation of a fine structure component in backscattered light from mucosal tissue which is periodic in wavelength. This structure is ordinarily masked by a diffusive background. We have identified the origin of this component as being due to light which is Mie scattered by surface epithelial cell nuclei. By analyzing the amplitude and frequency of the fine structure, the density and size distribution of these nuclei can be extracted. These quantities are important indicators of neoplastic precancerous changes in biological tissue.

  • Received 9 July 1997

DOI:https://doi.org/10.1103/PhysRevLett.80.627

©1998 American Physical Society

Authors & Affiliations

L. T. Perelman1, V. Backman1, M. Wallace2, G. Zonios1, R. Manoharan1, A. Nusrat3, S. Shields4, M. Seiler4, C. Lima1, T. Hamano1, I. Itzkan1, J. Van Dam2, J. M. Crawford5, and M. S. Feld1

  • 1G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
  • 2Gastroenterology Division, Brigham and Women's Hospital, Boston, Massachusetts 02115
  • 3Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115
  • 4U.S. Veterans Hospital, West Roxbury, Massachusetts 02132
  • 5Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023

References

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Issue

Vol. 80, Iss. 3 — 19 January 1998

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